Dr. Tomas Malinauskas
Contact information
Research groups
Collaborators
Tomas Malinauskas
Post Doctoral Research Associate
I am a structural biologist in Prof. Christian Siebold's group at the University of Oxford, UK. I use biochemical (mammalian cell-based protein expression, chromatography, cellular assays), biophysical (X-ray crystallography, cryo-EM, surface plasmon resonance, multi-angle light scattering) and computational (homology modelling, small molecule docking, evolutionary conservation analysis) tools to elucidate the molecular mechanisms of cell-to-cell communication. I aim to understand the way these mechanisms create and maintain living organisms.
If you need a structural perspective on your project, please email me. I am happy to help with anything from advice on protein constructs and expression to analysis of the target protein structure-function (e.g. the effect of mutations) to structural figures and movies for your papers!
Websites
Recent publications
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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
Journal article
Dubey R. et al, (2020), eLife, 9
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Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
Journal article
Rozbesky D. et al, (2019), Nature Communications, 10
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The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Journal article
Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982
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Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology.
Journal article
Masiulis S. et al, (2019), Nature, 566
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Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer.
Journal article
Laverty D. et al, (2019), Nature, 565, 516 - 520
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GABAA receptor signalling mechanisms revealed by structural pharmacology.
Journal article
Masiulis S. et al, (2019), Nature, 565, 454 - 459
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Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
Journal article
Gorvin CM. et al, (2018), Human Molecular Genetics, 27, 3720 - 3733
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A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling
Journal article
Gorvin CM. et al, (2018), Science Signaling, 11, eaan3714 - eaan3714
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Structural Basis for Growth Differentiation Factor 5 (GDF5) Signaling Inhibition by Repulsive Guidance Molecules (RGMs)
Conference paper
Malinauskas T. et al, (2018), BIOPHYSICAL JOURNAL, 114, 464A - 464A
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A Calcium-Sensing Receptor (CASR) Mutation Causes Hypocalcemia by Disrupting a Transmembrane Salt Bridge that Modulates beta-arrestin Signaling.
Conference paper
Gorvin C. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S133 - S133
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Structural Basis for Plexin Activation and Regulation
Journal article
Kong Y. et al, (2016), Neuron, 91, 548 - 560
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Next generation sequencing reveals a novel mutation in the XY-linker region of phospholipase C zeta (PLC zeta), resulting in truncated protein and oocyte activation deficiency
Conference paper
Amdani SN. et al, (2016), HUMAN REPRODUCTION, 31, 170 - 170
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Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry
Journal article
Malinauskas T. and Furukawa H., (2016), Structure, 24, 1008 - 1009
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Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry
Journal article
Malinauskas T. and Furukawa H., (2016), Structure, 24, 653 - 655
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Tailoring a Combination Preerythrocytic Malaria Vaccine
Journal article
Bauza K. et al, (2016), Infection and Immunity, 84, 622 - 634
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Genetic Control over mtDNA and Its Relationship to Major Depressive Disorder
Journal article
Cai N. et al, (2015), Current Biology, 25, 3170 - 3177
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Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders
Journal article
van Schouwenburg PA. et al, (2015), Clinical Immunology, 160, 301 - 314
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Extracellular modulators of Wnt signalling
Journal article
Malinauskas T. and Jones EY., (2014), Current Opinion in Structural Biology, 29, 77 - 84
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Genomes and phenomes of a population of outbred rats and its progenitors
Journal article
Baud A. et al, (2014), Scientific Data, 1
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Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1
Journal article
Zhao Y. et al, (2014), Structure, 22, 612 - 620
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Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1
Journal article
Zhao Y. et al, (2014), Structure, 22, 612 - 620
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Efficacy of a Plasmodium vivax Malaria Vaccine Using ChAd63 and Modified Vaccinia Ankara Expressing Thrombospondin-Related Anonymous Protein as Assessed with Transgenic Plasmodium berghei Parasites
Journal article
Bauza K. et al, (2014), Infection and Immunity, 82, 1277 - 1286
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Abstract
Journal article
(2013)
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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
Journal article
Nachtergaele S. et al, (2013), eLife, 2
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Structural insights into proteoglycan-shaped Hedgehog signaling
Journal article
Whalen DM. et al, (2013), Proceedings of the National Academy of Sciences, 110, 16420 - 16425
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Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Journal article
(2013), Nature Genetics, 45, 767 - 775
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Neuropilins Lock Secreted Semaphorins onto Plexins in a Ternary Signalling Complex
Conference paper
Malinauskas T. et al, (2013), Biophysical Journal, 104, 613a - 613a
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Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
Journal article
Janssen BJC. et al, (2012), Nature Structural & Molecular Biology, 19, 1293 - 1299
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Correction
Journal article
(2012), Biophysical Journal, 102, 1468 - 1468
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High-throughput Molecular Docking Now in Reach for a Wider Biochemical Community
Conference paper
Balan DM. et al, (2012), 2012 20th Euromicro International Conference on Parallel, Distributed and Network-based Processing
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Modular Mechanism of Wnt Signalling Inhibition by Wnt Inhibitory Factor 1
Journal article
Malinauskas T. et al, (2012), Biophysical Journal, 102, 518a - 518a
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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
Journal article
Chen S. et al, (2011), Developmental Cell, 21, 848 - 861
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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
Journal article
Malinauskas T. et al, (2011), Nature Structural & Molecular Biology, 18, 886 - 893
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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1
Journal article
Malinauskas T. et al, (2011), Nature Structural and Molecular Biology, 18, 886 - 893
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Docking of Fatty Acids into the WIF Domain of the Human Wnt Inhibitory Factor-1
Journal article
Malinauskas T., (2008), Lipids, 43, 227 - 230
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Prussian blue-based amperometric sensor as a tool for the study of Pichia pastoris alcohol oxidase-catalyzed reactions
Journal article
Malinauskas T. and Malinauskas A., (2005), BULLETIN OF ELECTROCHEMISTRY, 21, 289 - 295