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Tomas Malinauskas

Tomas Malinauskas

Contact information


tomas@strubi.ox.ac.uk
tomas.malinauskas@gmail.com


ORCID ID https://orcid.org/0000-0002-4847-5529


Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom

Collaborators

Tomas Malinauskas

Post Doctoral Research Associate

I am a structural biologist in Prof. Christian Siebold's group at the University of Oxford, UK. I use biochemical (mammalian cell-based protein expression, chromatography, cellular assays), biophysical (X-ray crystallography, cryo-EM, SPR, BLI, MALS) and computational (homology modelling, small molecule docking, evolutionary conservation analysis) tools to elucidate the molecular mechanisms of cell-to-cell communication. I aim to understand the way these mechanisms create and maintain living organisms.

If you need a structural perspective on your project, please email me. I am happy to help with anything from advice on protein constructs and expression to analysis of the target protein structure-function (e.g. the effect of mutations) to structural figures and movies for your papers.

Selected publications:

1. Robinson, R.A.*, Griffiths, S.C.*, van de Haar, L.L.*, Malinauskas, T.*, et al. Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 1–18 (2021).

2. Malinauskas, T.**, et al. Repulsive Guidance Molecules lock Growth Differentiation Factor 5 in an inhibitory complex. Proc. Natl. Acad. Sci. U.S.A., 117 (27), 15620–15631 (2020).

3. Zhao, Y.*, Malinauskas, T.*, et al. Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-Activated Inhibitory Factor 1. Structure, 22 (4), 612–620 (2014).

4. Janssen, B.J.C.*, Malinauskas, T.*, et al. Neuropilins lock secreted semaphorins onto plexins in a ternary signalling complex. Nat. Struct. Mol. Biol., 19 (12), 1293–1299 (2012).

5. Malinauskas, T., et al. Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. Nat. Struct. Mol. Biol., 18 (8), 886–893 (2011).

*Equal contribution.

**Co-corresponding author.

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