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Publications

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Willis NJ. et al, (2022), Journal of medicinal chemistry

An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status

Lumley SF. et al, (2022), Clinical Infectious Diseases, 74, 1208 - 1219

IceBreaker: Software for high-resolution single-particle cryo-EM with non-uniform ice

Olek M. et al, (2022), Structure, 30, 522 - 531.e4

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Li D. et al, (2022), Commun Biol, 5

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

Ng WM. et al, (2022), mBio

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

Ng W. et al, (2022)

Peptoid-Directed Formation of Five-Fold Twinned Au Nanostars through Particle Attachment and Facet Stabilization.

Jin B. et al, (2022), Angewandte Chemie (International ed. in English)

Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

Wei J. et al, (2022), Nature Medicine

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai W. et al, (2022), Cell, 185, 467 - 484.e15

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Baddock HT. et al, (2022), Nucleic Acids Research

High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity.

Ni T. et al, (2022), Nature protocols

The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a.

Veler H. et al, (2022), Journal of virology

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

Huang K-YA. et al, (2022), THERANOSTICS, 12, 1 - 17

Structural Analysis of Retrovirus Assembly and Maturation.

Krebs A-S. et al, (2021), Viruses, 14

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum.

Dejnirattisai W. et al, (2021), Lancet (London, England)

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Molecular cell, 81, 5025 - 5038.e10

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai W. et al, (2021)

A structural view of the SARS-CoV-2 virus and its assembly.

Hardenbrook NJ. and Zhang P., (2021), Curr Opin Virol, 52, 123 - 134

Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.

Zhang J. et al, (2021), Nat Commun, 12

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