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Publications

High-resolution in situ structure determination by cryo-electron tomography and subtomogram averaging using emClarity.

Ni T. et al, (2022), Nature protocols

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

Huang K-YA. et al, (2022), THERANOSTICS, 12, 1 - 17

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai W. et al, (2021)

A structural view of the SARS-CoV-2 virus and its assembly.

Hardenbrook NJ. and Zhang P., (2021), Curr Opin Virol, 52, 123 - 134

Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.

Zhang J. et al, (2021), Nat Commun, 12

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Tan TK. et al, (2021), Nature Communications, 12

A single dose of ChAdOx1 Chik vaccine induces neutralizing antibodies against four chikungunya virus lineages in a phase 1 clinical trial

Folegatti PM. et al, (2021), Nature Communications, 12

Bacteriophage PRD1 as a nanoscaffold for drug loading.

Duyvesteyn HME. et al, (2021), Nanoscale

CryoEM structure of the super-constricted two-start dynamin 1 filament

Liu J. et al, (2021), Nature Communications, 12

Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins

Renner M. et al, (2021), Nature Communications, 12

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

Oliver MR. et al, (2021), Nature Communications, 12

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Griffiths SC. et al, (2021), Nature Communications, 12

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Spencer AJ. et al, (2021), Nature Communications, 12

Probing the biogenesis pathway and dynamics of thylakoid membranes

Huokko T. et al, (2021), Nature Communications, 12

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

Liu C. et al, (2021), Cell Host Microbe

Structure of native HIV-1 cores and their interactions with IP6 and CypA.

Ni T. et al, (2021), Sci Adv, 7

Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2

Tang Q. et al, (2021), Viruses, 13, 2214 - 2214

Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

Xiao G. et al, (2021), Bioorganic & Medicinal Chemistry, 50, 116477 - 116477

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