Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

PI480.jpg

Glycoproteins feature on the surface of many enveloped viruses, and as such, are attractive targets for therapeutic design. Through the application of techniques in structural biology, immunology, and cell biology, our group aims to harness knowledge of glycoprotein structure and function to inform upon the rational development of therapeutics and preventive medicines. We have a particular interest in the development and characterisation of neutralising and protective monoclonal antibodies and look to apply the insights gleaned from our biophysical studies to identify sites of vulnerability that may be targeted through rational vaccine design. 

 

 

 

 

 

 

 

 

 

 

Our team

Selected publications

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.

Journal article

Faria NR. et al, (2021), Science (New York, N.Y.), 372, 815 - 821

A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex.

Journal article

Avanzato VA. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America, 116, 25057 - 25067

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus

Journal article

Allen ER. et al, (2018), Cell Reports, 25, 3750 - 3758.e4

Toremifene interacts with and destabilizes the Ebola virus glycoprotein

Journal article

Zhao Y. et al, (2016), Nature, 535, 169 - 172

Zika virus in the Americas: Early epidemiological and genetic findings

Journal article

Faria NR. et al, (2016), Science, 352, 345 - 349