Contact information
Research groups
Yuguang Zhao
Instruct Senior Scientist
Recent publications
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Caffeine inhibits Notum activity by binding at the catalytic pocket
Journal article
Zhao Y. et al, (2020), Communications Biology, 3
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Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Journal article
Zhao Y. et al, (2020), Nature Communications, 11
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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2.
Journal article
Huo J. et al, (2020), Nature structural & molecular biology
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
Journal article
Zhou D. et al, (2020), Nature Structural & Molecular Biology, 27, 950 - 958
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike
Journal article
Huo J. et al, (2020), Cell Host & Microbe, 28, 445 - 454.e6
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Journal article
Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 846 - 854
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Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
Journal article
Mahy W. et al, (2020), Journal of Medicinal Chemistry
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Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Journal article
Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260
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Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
Journal article
Zhao Y. et al, (2020), Journal of Pineal Research, 68
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Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Journal article
Atkinson BN. et al, (2020), Bioorganic & medicinal chemistry letters, 30