Yuguang Zhao
Contact information
01865-287551
https://orcid.org/0000-0001-8916-8552
Division of Structural Biology (STRUBI), Wellcome Centre for Human Genetics (WCHG), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Yuguang Zhao
Instruct Senior Scientist
Wnt Signalling
Viruses, Receptors and Small Molecules
Websites
Recent publications
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Structural Analysis and Development of Notum Fragment Screening Hits.
Journal article
Zhao Y. et al, (2022), ACS chemical neuroscience
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Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
Powell GT. et al, (2022)
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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Journal article
Willis NJ. et al, (2022), Journal of medicinal chemistry
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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2021), Journal of Medicinal Chemistry
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Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.
Journal article
Graham C. et al, (2021), Immunity, 54, 1276 - 1289.e6
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Antibody evasion by the P.1 strain of SARS-CoV-2
Journal article
Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9
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Small-molecule inhibitors of carboxylesterase Notum
Journal article
Zhao Y. et al, (2021), Future Medicinal Chemistry
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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
Journal article
Zhou D. et al, (2021), Cell, 184, 2348 - 2361.e6
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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
Journal article
Supasa P. et al, (2021), Cell, 184, 2201 - 2211.e7
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The antigenic anatomy of SARS-CoV-2 receptor binding domain
Journal article
Dejnirattisai W. et al, (2021), Cell, 184, 2183 - 2200.e22