Yuguang Zhao
Contact information
01865-287551
https://orcid.org/0000-0001-8916-8552
Division of Structural Biology (STRUBI), Wellcome Centre for Human Genetics (WCHG), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Yuguang Zhao
Instruct Senior Scientist
Wnt Signalling
Viruses, Receptors and Small Molecules
Websites
Recent publications
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Structural insights into Frizzled3 through nanobody modulators.
Hillier J. et al, (2024), Nat Commun, 15
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Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
Powell GT. et al, (2024), Science, 384, 573 - 579
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Switching of Receptor Binding Poses between Closely Related Enteroviruses
Zhou D. et al, (2022), Viruses, 14, 2625 - 2625
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Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao Y. et al, (2022), ACS chemical neuroscience
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Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
Powell GT. et al, (2022)
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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Willis NJ. et al, (2022), Journal of medicinal chemistry
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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Steadman D. et al, (2021), Journal of Medicinal Chemistry
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Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.
Graham C. et al, (2021), Immunity, 54, 1276 - 1289.e6
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Antibody evasion by the P.1 strain of SARS-CoV-2
Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9
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Small-molecule inhibitors of carboxylesterase Notum
Zhao Y. et al, (2021), Future Medicinal Chemistry