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Ray Owens

Ray Owens

Contact information


ray.owens@strubi.ox.ac.uk


Professor Ray Owens' Research Group


Protein Production UK

Automated construction and screening of protein expression 
Automated imaging of protein crystallization experiments

Ray Owens

Professor of Molecular

Protein Production UK (PPUK)  is being developed as a programme for protein engineering and production as part of the Structural Biology theme of the Rosalind Franklin Institute (RFI).  PPUK aims to develop new and innovative methods and to work in partnership with academic groups and industry to enable uptake of the technology.

PPUK has an established pipeline for protein production based on the technology developed by the Oxford Protein Production Facility (OPPF), involving construction of multi-purpose vectors (e.g. for producing complexes, and membrane proteins), high-throughput expression screening in different cell hosts (microbial, insect and mammalian cells) combined with scale-up to multi-litre culture volumes and downstream processing. New technology platforms that are under development include production of single-domain antibodies for the stabilisation of membrane proteins for analysis by cryo-EM.