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Publications

Switching of Receptor Binding Poses between Closely Related Enteroviruses

Zhou D. et al, (2022), Viruses, 14, 2625 - 2625

Structural Analysis and Development of Notum Fragment Screening Hits.

Zhao Y. et al, (2022), ACS chemical neuroscience

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Powell GT. et al, (2022)

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Willis NJ. et al, (2022), Journal of medicinal chemistry

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.

Graham C. et al, (2021), Immunity, 54, 1276 - 1289.e6

Antibody evasion by the P.1 strain of SARS-CoV-2

Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9

Small-molecule inhibitors of carboxylesterase Notum

Zhao Y. et al, (2021), Future Medicinal Chemistry

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Zhou D. et al, (2021), Cell, 184, 2348 - 2361.e6

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Supasa P. et al, (2021), Cell, 184, 2201 - 2211.e7

The antigenic anatomy of SARS-CoV-2 receptor binding domain

Dejnirattisai W. et al, (2021), Cell, 184, 2183 - 2200.e22

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Huo J. et al, (2021), Nature Structural & Molecular Biology, 28, 326 - 326

Notum Deacylates Octanoylated Ghrelin

Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201

Caffeine inhibits Notum activity by binding at the catalytic pocket

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Zhao Y. et al, (2020), Nature Communications, 11

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 1094 - 1094

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Mahy W. et al, (2020), Journal of Medicinal Chemistry

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

Zhou D. et al, (2020), Nature Structural & Molecular Biology, 27, 950 - 958

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

Huo J. et al, (2020), Cell Host & Microbe, 28, 445 - 454.e6

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 846 - 854

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