Structural insights into Frizzled3 through nanobody modulators.
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Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
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Switching of Receptor Binding Poses between Closely Related Enteroviruses
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Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao Y. et al, (2022), ACS chemical neuroscience
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant.
Graham C. et al, (2021), Immunity, 54, 1276 - 1289.e6
Antibody evasion by the P.1 strain of SARS-CoV-2
Dejnirattisai W. et al, (2021), Cell, 184, 2939 - 2954.e9
Small-molecule inhibitors of carboxylesterase Notum
Zhao Y. et al, (2021), Future Medicinal Chemistry
Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
Zhou D. et al, (2021), Cell, 184, 2348 - 2361.e6
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
Supasa P. et al, (2021), Cell, 184, 2201 - 2211.e7
The antigenic anatomy of SARS-CoV-2 receptor binding domain
Dejnirattisai W. et al, (2021), Cell, 184, 2183 - 2200.e22
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Huo J. et al, (2021), Nature Structural & Molecular Biology, 28, 326 - 326
Caffeine inhibits Notum activity by binding at the catalytic pocket
Zhao Y. et al, (2020), Communications Biology, 3
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Zhao Y. et al, (2020), Nature Communications, 11
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Huo J. et al, (2020), Nature Structural & Molecular Biology, 27, 1094 - 1094
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
Mahy W. et al, (2020), Journal of Medicinal Chemistry
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
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