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Hillier J. et al, (2024), Nat Commun, 15
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Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
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Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain
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Structural Analysis and Development of Notum Fragment Screening Hits.
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Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes
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The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs.
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Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
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Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
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Caffeine inhibits Notum activity by binding at the catalytic pocket
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Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Zhao Y. et al, (2020), Nature Communications, 11
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
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Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
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