Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
Journal article
Li D. et al, (2022), Commun Biol, 5
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2021), Journal of Medicinal Chemistry
Small-molecule inhibitors of carboxylesterase Notum
Journal article
Zhao Y. et al, (2021), Future Medicinal Chemistry
Notum Deacylates Octanoylated Ghrelin
Journal article
Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201
Caffeine inhibits Notum activity by binding at the catalytic pocket
Journal article
Zhao Y. et al, (2020), Communications Biology, 3
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Journal article
Zhao Y. et al, (2020), Nature Communications, 11
Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Journal article
Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5
The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs
Journal article
Jackson V. et al, (2020)
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
Journal article
Mahy W. et al, (2020), Journal of Medicinal Chemistry
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.
Journal article
Schwerd T. et al, (2020), Bone Res, 8
Structural basis of semaphorin‐plexin cis interaction
Journal article
Rozbesky D. et al, (2020), The EMBO Journal
Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility
Journal article
Rozbesky D. et al, (2020), Structure, 28, 507 - 515.e5
Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Journal article
Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260
Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.
Journal article
Rozbesky D. and Jones EY., (2019), Current opinion in structural biology, 61, 79 - 85
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
Journal article
Rozbesky D. et al, (2019), Nature Communications, 10
Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells
Journal article
Barnkob MB. et al, (2019)
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
Journal article
Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Journal article
Atkinson BN. et al, (2019), MedChemComm, 10, 1361 - 1369
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
Journal article
van der Klaauw AA. et al, (2019), Cell, 176, 729 - 742.e18
Designer protein delivers signal of choice
Journal article
Jones EY., (2019), Nature, 565, 165 - 166