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Publications

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.

Li D. et al, (2022), Commun Biol, 5

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Steadman D. et al, (2021), Journal of Medicinal Chemistry

Small-molecule inhibitors of carboxylesterase Notum

Zhao Y. et al, (2021), Future Medicinal Chemistry

Notum Deacylates Octanoylated Ghrelin

Zhao Y. et al, (2021), Molecular Metabolism, 101201 - 101201

Caffeine inhibits Notum activity by binding at the catalytic pocket

Zhao Y. et al, (2020), Communications Biology, 3

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Zhao Y. et al, (2020), Nature Communications, 11

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.

Bochel AJ. et al, (2020), Structure (London, England : 1993), 28, 1300 - 1312.e5

The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs

Jackson V. et al, (2020)

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity

Mahy W. et al, (2020), Journal of Medicinal Chemistry

A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.

Schwerd T. et al, (2020), Bone Res, 8

Structural basis of semaphorin‐plexin cis interaction

Rozbesky D. et al, (2020), The EMBO Journal

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility

Rozbesky D. et al, (2020), Structure, 28, 507 - 515.e5

Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8

Zhao Y. et al, (2020), Journal of Medicinal Chemistry, 63, 3252 - 3260

Cell guidance ligands, receptors and complexes - orchestrating signalling in time and space.

Rozbesky D. and Jones EY., (2019), Current opinion in structural biology, 61, 79 - 85

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Rozbesky D. et al, (2019), Nature Communications, 10

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

Barnkob MB. et al, (2019)

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Atkinson BN. et al, (2019), MedChemComm, 10, 1361 - 1369

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance

van der Klaauw AA. et al, (2019), Cell, 176, 729 - 742.e18

Designer protein delivers signal of choice

Jones EY., (2019), Nature, 565, 165 - 166

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