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Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

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McGough IJ. et al, (2020), Nature, 585, 85 - 90

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

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Rozbesky D. et al, (2019), Nature Communications, 10

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

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Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

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iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

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Chen S. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America, 116, 17470 - 17479

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

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Kowatsch C. et al, (2019), Current opinion in structural biology, 57, 204 - 214

Biochemical mechanisms of vertebrate hedgehog signaling.

Journal article

Kong JH. et al, (2019), Development (Cambridge, England), 146

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

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Hedger G. et al, (2019), Structure (London, England : 1993), 27, 549 - 559.e2

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

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Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Cilia-Associated Oxysterols Activate Smoothened

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Raleigh DR. et al, (2018), Molecular Cell, 72, 316 - 327.e5

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

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Byrne EFX. et al, (2018), Current Opinion in Cell Biology, 51, 81 - 88

Structural Basis for Growth Differentiation Factor 5 (GDF5) Signaling Inhibition by Repulsive Guidance Molecules (RGMs)

Conference paper

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RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

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Siebold C. et al, (2017), Trends in Cell Biology, 27, 365 - 378

Molecular Dynamics Simulations of G-Protein Coupled Receptor Lipid Interactions


Hedger G. et al, (2017), Biophysical Journal, 112, 386a - 386a

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