Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Journal article
Coupland CE. et al, (2021), Molecular cell, 81, 5025 - 5038.e10
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling
Journal article
Griffiths SC. et al, (2021), Nature Communications, 12
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.
Journal article
Kinnebrew M. et al, (2021), eLife, 10
Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Journal article
Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
Journal article
Griffiths S. et al, (2021)
Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Journal article
Ansell TB. et al, (2021)
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Journal article
Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Journal article
Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31
The Energetics of Cholesterol Transport through Patched1: MD Simulations and Free Energy Calculations
Conference paper
Ansell TB. et al, (2021), BIOPHYSICAL JOURNAL, 120, 72A - 72A
Cholesterol access in cellular membranes controls Hedgehog signaling.
Journal article
Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313
Glypicans shield the Wnt lipid moiety to enable signalling at a distance.
Journal article
McGough IJ. et al, (2020), Nature, 585, 85 - 90
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Journal article
Malinauskas T. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 15620 - 15631
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.
Journal article
Dubey R. et al, (2020), eLife, 9
Cholesterol and Patched1: MD Simulation Studies
Conference paper
Ansell TB. et al, (2020), BIOPHYSICAL JOURNAL, 118, 363A - 363A
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
Journal article
Rozbesky D. et al, (2019), Nature Communications, 10
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Journal article
Kinnebrew M. et al, (2019), eLife, 8
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Journal article
Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
Journal article
Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479
Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.
Journal article
Kowatsch C. et al, (2019), Current opinion in structural biology, 57, 204 - 214