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Publications

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Molecular cell, 81, 5025 - 5038.e10

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Griffiths SC. et al, (2021), Nature Communications, 12

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

Kinnebrew M. et al, (2021), eLife, 10

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

Griffiths S. et al, (2021)

Structure and Mechanism of Hedgehog Acyl Transferase

Coupland CE. et al, (2021)

Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Ansell TB. et al, (2021)

Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.

Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31

The Energetics of Cholesterol Transport through Patched1: MD Simulations and Free Energy Calculations

Ansell TB. et al, (2021), BIOPHYSICAL JOURNAL, 120, 72A - 72A

Cholesterol access in cellular membranes controls Hedgehog signaling.

Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.

Malinauskas T. et al, (2020), Proceedings of the National Academy of Sciences of the United States of America, 117, 15620 - 15631

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling.

Dubey R. et al, (2020), eLife, 9

Cholesterol and Patched1: MD Simulation Studies

Ansell TB. et al, (2020), BIOPHYSICAL JOURNAL, 118, 363A - 363A

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Rozbesky D. et al, (2019), Nature Communications, 10

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Chen S. et al, (2019), Proceedings of the National Academy of Sciences, 116, 17470 - 17479

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C. et al, (2019), Current opinion in structural biology, 57, 204 - 214

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