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Publications

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

McGough IJ. et al, (2020), Nature, 585, 85 - 90

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Rozbesky D. et al, (2019), Nature Communications, 10

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Kinnebrew M. et al, (2019), eLife, 8

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF. et al, (2019), Nature chemical biology, 15, 975 - 982

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Chen S. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America, 116, 17470 - 17479

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C. et al, (2019), Current opinion in structural biology, 57, 204 - 214

Robin Hood: non-fitting, non-smoothing image detrending for bleaching correction

Nolan R. et al, (2019)

Biochemical mechanisms of vertebrate hedgehog signaling.

Kong JH. et al, (2019), Development (Cambridge, England), 146

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Hedger G. et al, (2019), Structure (London, England : 1993), 27, 549 - 559.e2

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

Lanyon-Hogg T. et al, (2019), Chemical Science, 10, 8995 - 9000

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

Elegheert J. et al, (2018), Nature Protocols, 13, 2991 - 3017

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias

Gorvin CM. et al, (2018), Human Molecular Genetics, 27, 3720 - 3733

Cilia-Associated Oxysterols Activate Smoothened

Raleigh DR. et al, (2018), Molecular Cell, 72, 316 - 327.e5

Calibration-free In Vitro Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software

Nolan R. et al, (2018), Journal of Visualized Experiments

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

Byrne EFX. et al, (2018), Current Opinion in Cell Biology, 51, 81 - 88

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

Gorvin CM. et al, (2018), Science Signaling, 11, eaan3714 - eaan3714

Structural Basis for Growth Differentiation Factor 5 (GDF5) Signaling Inhibition by Repulsive Guidance Molecules (RGMs)

Malinauskas T. et al, (2018), BIOPHYSICAL JOURNAL, 114, 464A - 464A

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

Siebold C. et al, (2017), Trends in Cell Biology, 27, 365 - 378

Molecular Dynamics Simulations of G-Protein Coupled Receptor Lipid Interactions

Hedger G. et al, (2017), Biophysical Journal, 112, 386a - 386a

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP

Lu M. et al, (2016), Cancer Cell, 30, 822 - 823

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