Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis.
Journal article
Bakhshalizadeh S. et al, (2024), Molecular and cellular endocrinology
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.
Journal article
Ritzefeld M. et al, (2024), Journal of medicinal chemistry
LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.
Journal article
Ansell TB. et al, (2023), Nature communications, 14
The energetics and ion coupling of cholesterol transport through Patched1
Journal article
Ansell TB. et al, (2023), Science Advances, 9
Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family.
Journal article
Coupland CE. et al, (2023), Curr Opin Struct Biol, 80
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.
Journal article
Siebold C. and Rohatgi R., (2023), Annu Rev Biochem
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling
Journal article
Griffiths SC. et al, (2021), Nature Communications, 12
Structure, mechanism, and inhibition of Hedgehog acyltransferase
Journal article
Coupland CE. et al, (2021), Molecular Cell, 81, 5025 - 5038.e10
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.
Journal article
Kinnebrew M. et al, (2021), eLife, 10
Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Journal article
Ansell TB. et al, (2021), Journal of Chemical Theory and Computation, 17, 6548 - 6558
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
Journal article
Griffiths S. et al, (2021)
Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**
Journal article
Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659
Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Journal article
Ansell TB. et al, (2021)
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Journal article
Lanyon-Hogg T. et al, (2021), Angewandte Chemie (International ed. in English), 60, 13542 - 13547
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Journal article
Robinson RA. et al, (2021), Cell, 184, 2103 - 2120.e31
The Energetics of Cholesterol Transport through Patched1: MD Simulations and Free Energy Calculations
Conference paper
Ansell TB. et al, (2021), BIOPHYSICAL JOURNAL, 120, 72A - 72A
Cholesterol access in cellular membranes controls Hedgehog signaling.
Journal article
Radhakrishnan A. et al, (2020), Nature chemical biology, 16, 1303 - 1313
Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase
Preprint
Lanyon-Hogg T. et al, (2020)
Glypicans shield the Wnt lipid moiety to enable signalling at a distance.
Journal article
McGough IJ. et al, (2020), Nature, 585, 85 - 90