Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
Zeltina A., Krumm SA., Sahin M., Struwe WB., Harlos K., Nunberg JH., Crispin M., Pinschewer DD., Doores KJ., Bowden TA.
Significance An estimated 5 million people are at risk of infection by Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever. JUNV displays a glycoprotein spike complex on the surface of the viral envelope that is responsible for negotiating host-cell recognition and entry. Herein, we show that monoclonal antibodies that have gone through different germline selection pathways have converged to target the host-cell receptor-binding site on the JUNV glycoprotein spike. Immunofocusing of the antibody response to mimic natural host–receptor interactions reveals a key point of vulnerability on the JUNV surface.