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Significance An estimated 5 million people are at risk of infection by Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever. JUNV displays a glycoprotein spike complex on the surface of the viral envelope that is responsible for negotiating host-cell recognition and entry. Herein, we show that monoclonal antibodies that have gone through different germline selection pathways have converged to target the host-cell receptor-binding site on the JUNV glycoprotein spike. Immunofocusing of the antibody response to mimic natural host–receptor interactions reveals a key point of vulnerability on the JUNV surface.

Original publication




Journal article


Proceedings of the National Academy of Sciences


Proceedings of the National Academy of Sciences

Publication Date





7031 - 7036