Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen
Rissanen I., Krumm SA., Stass R., Whitaker A., Voss JE., Bruce EA., Rothenberger S., Kunz S., Burton DR., Huiskonen JT., Botten JW., Bowden TA., Doores KJ.
The spillover of pathogenic hantaviruses from rodent reservoirs into the human population poses a continued threat to human health. Here, we show that a recombinant form of the Hantaan virus (HTNV) surface-displayed glycoprotein, Gn, elicits a neutralizing antibody response in rabbits.