Publications
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Structural characterization of the full-length Hantaan virus polymerase
Keown JR. et al, (2024), PLOS Pathogens, 20, e1012781 - e1012781
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Open architecture of archaea MCM and dsDNA complexes resolved using monodispersed streptavidin affinity CryoEM
Ma J. et al, (2024), Nature Communications, 15
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Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels.
Hooda Y. et al, (2024)
News
The first publication from our newly installed Plasma FIB Arctis microscope
15 January 2025
The study used the Plasma FIB Arctis to mill thin cellular lamella samples which were then imaged on our Krios using cryo-electron tomography, to examine transient alterations of the nuclear envelope. This revealed a new mechanism by which cells repair DNA damage caused by TOP1cc, highlighting the crucial role of selective autophagy and the protein TEX264 in maintaining genome stability and cell survival.
£3.7 million Wellcome Trust Discovery Award, led by Professor David Strutt (University of Sheffield) and Professor Yvonne Jones will focus on unravelling how symmetry breaking establishes planar polarity—the coordinated orientation of cells across a tissue plane.
15 January 2025
Using advanced imaging technologies, including light and electron cryo-microscopy, alongside molecular, cellular, and genetic tools, the team will build a detailed understanding of how protein complexes and cells achieve symmetry breaking to form polarised structures.
Peijun Zhang elected to European Molecular Biology Organization membership
15 November 2024
Congratulations to Prof. Peijun Zhang among 120 scientists from across Europe and beyond has been elected to the European Molecular Biology Organization (EMBO) membership, an honour that celebrates research excellence and outstanding achievements in the life sciences.
Graduate studies
The Division of Structural Biology (STRUBI) is a research centre of excellence for the study of the molecular and structural basis of biology. Students in STRUBI study a wide range of problems from a structural and mechanistic perspective using a range of structural biology methods including X-ray Crystallography, cryo-electron microscopy, NMR and other biophysical and biochemical methods.