Yuguang Zhao
Contact information
01865-287551
https://orcid.org/0000-0001-8916-8552
Division of Structural Biology (STRUBI), Wellcome Centre for Human Genetics (WCHG), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
Yuguang Zhao
Instruct Senior Scientist
Wnt Signalling
Viruses, Receptors and Small Molecules
Websites
Recent publications
TSC2/mTORC1 integrates deoxynivalenol signals recognized by membrane receptors IR and EGFR to restrict intestinal stem cell function
Journal article
Dou C-X. et al, (2025), Journal of Hazardous Materials, 494, 138769 - 138769
Structural insights into Frizzled3 through nanobody modulators
Journal article
Hillier J. et al, (2024), Nature Communications, 15
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
Journal article
Powell GT. et al, (2024), Science, 384, 573 - 579
Switching of Receptor Binding Poses between Closely Related Enteroviruses
Journal article
Zhou D. et al, (2022), Viruses, 14, 2625 - 2625
Structural Analysis and Development of Notum Fragment Screening Hits
Journal article
Zhao Y. et al, (2022), ACS Chemical Neuroscience, 13, 2060 - 2077
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Journal article
Willis NJ. et al, (2022), Journal of Medicinal Chemistry, 65, 7212 - 7230
Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character
Preprint
Powell GT. et al, (2022)
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
Journal article
Steadman D. et al, (2022), Journal of Medicinal Chemistry, 65, 562 - 578
Structural Insights into Notum Covalent Inhibition
Journal article
Zhao Y. et al, (2021), Journal of Medicinal Chemistry, 64, 11354 - 11363
Notum deacylates octanoylated ghrelin
Journal article
Zhao Y. et al, (2021), Molecular Metabolism, 49, 101201 - 101201