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<jats:p>Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.</jats:p>

Original publication

DOI

10.1128/jvi.02298-13

Type

Journal article

Journal

Journal of Virology

Publisher

American Society for Microbiology

Publication Date

01/12/2013

Volume

87

Pages

13070 - 13075