Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes

Lanyon-Hogg T., Ritzefeld M., Sefer L., Bickel JK., Rudolf AF., Panyain N., Bineva-Todd G., Ocasio CA., O'Reilly N., Siebold C., Magee AI., Tate EW.

A highly accurate and versatile fluorescence polarisation assay for any enzyme adding or removing lipid posttranslational modifications, with the potential to accelerate drug discovery against these targets.

DOI

10.1039/c9sc01785b

Type

Journal article

Journal

Chemical Science

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2019

Volume

10

Pages

8995 - 9000

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