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Talk title: Structure, host-factor binding, and inhibition of the HIV-1 capsid

 

Abstract: The mature capsid of HIV-1 packages the viral genome for delivery into new host cells. Upon entry, the capsid performs multiple essential functions to protect the viral nucleic acids from innate immune sensors, facilitate reverse transcription of the viral RNA into double-stranded DNA, engage with the cytoskeleton to traffic from the entry site at the plasma membrane to the nucleus, mediate transport through the nuclear pore, and ultimately uncoats to facilitate integration of the viral DNA into the host chromosome. Our group uses structural, biochemical, and virological approaches to understand how the fullerene cone HIV-1 capsid performs these essential functions. In this presentation, I will discuss our discoveries that connect capsid structure with binding to post-entry host factors that facilitate or disrupt viral replication.

More information about the speaker can be found here