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Yuguang Zhao

Yuguang Zhao

Contact information


yuguang.zhao@strubi.ox.ac.uk


01865-287551


ORCID ID https://orcid.org/0000-0001-8916-8552


Division of Structural Biology (STRUBI), Wellcome Centre for Human Genetics (WCHG), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK

Yuguang Zhao

Instruct Senior Scientist

Wnt Signalling

Viruses, Receptors and Small Molecules

Recent publications

TSC2/mTORC1 integrates deoxynivalenol signals recognized by membrane receptors IR and EGFR to restrict intestinal stem cell function

Journal article

Dou C-X. et al, (2025), Journal of Hazardous Materials, 494, 138769 - 138769

Structural insights into Frizzled3 through nanobody modulators

Journal article

Hillier J. et al, (2024), Nature Communications, 15

Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

Journal article

Powell GT. et al, (2024), Science, 384, 573 - 579

Switching of Receptor Binding Poses between Closely Related Enteroviruses

Journal article

Zhou D. et al, (2022), Viruses, 14, 2625 - 2625

Structural Analysis and Development of Notum Fragment Screening Hits

Journal article

Zhao Y. et al, (2022), ACS Chemical Neuroscience, 13, 2060 - 2077

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit

Journal article

Willis NJ. et al, (2022), Journal of Medicinal Chemistry, 65, 7212 - 7230

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Preprint

Powell GT. et al, (2022)

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity

Journal article

Steadman D. et al, (2022), Journal of Medicinal Chemistry, 65, 562 - 578

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

Journal article

Huang K-YA. et al, (2022), Theranostics, 12, 1 - 17

Structural Insights into Notum Covalent Inhibition

Journal article

Zhao Y. et al, (2021), Journal of Medicinal Chemistry, 64, 11354 - 11363