A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

Gorvin CM., Babinsky VN., Malinauskas T., Nissen PH., Schou AJ., Hanyaloglu AC., Siebold C., Jones EY., Hannan FM., Thakker RV.

A disease-associated mutation disrupts a calcium-sensing receptor structural motif and causes biased signaling through β-arrestin.

DOI

10.1126/scisignal.aan3714

Type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

2018-02-20T00:00:00+00:00

Volume

11

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