We reexamine major membrane models against current evidence. Each addresses important questions, but not all are consistent with the available data. Seeking coherence, we propose the strong proteolipid code, a framework of versioned submodels building on an earlier proposal that clarified the relationship between protein and lipid distributions. The first of these submodels introduces glue-field duality as a structure for lipid-mediated protein interactions, classifies protein islands, and bounds autonomous lipid behavior.
Journal article
2026-07-01T00:00:00+00:00
Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, U.K.