Membrane Models and the Pursuit of Coherence.

Kervin TA., Zhang Z., Clark M., Overduin M., Zhang P.

We reexamine major membrane models against current evidence. Each addresses important questions, but not all are consistent with the available data. Seeking coherence, we propose the strong proteolipid code, a framework of versioned submodels building on an earlier proposal that clarified the relationship between protein and lipid distributions. The first of these submodels introduces glue-field duality as a structure for lipid-mediated protein interactions, classifies protein islands, and bounds autonomous lipid behavior.

DOI

10.1021/acs.biochem.6c00367

Type

Journal article

Publication Date

2026-07-01T00:00:00+00:00

Addresses

Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, U.K.

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