Research

Professor Robert Gilbert

miRNA maturation is switched by 3' uridylylation of pre-miRNA forms. We are studying this process using the yeast enzyme Cid1 and its close human homologues ZCCHC6 and ZCCHC11. The left hand region of
Pores formed by membrane attack complex-perforin/cholesterol-dependent cytolysin proteins (MACPF/CDCs). These proteins are found in all different forms of cellular life and play key roles in infection

Our work is focused on molecular mechanisms underlying pathology in humans, specifically cancer and membrane pore formation and cell adhesion. We are studying mechanisms of 3' uridylation of RNAs with clear effects in tumourigenesis and are engaged in related translational research in collaboration with the Target Discovery Institute and Cancer Research Technology. We are also working on mechanisms of pore formation relevant to inflammation and cytotoxic T cell activity, and to infection processes in diseases such as malaria and toxoplasmosis. Our work on membrane biology in disease includes a focus on the kindlin proteins which are involved both in cell adhesion activation and also function nuclearly in suppression of tumour-suppressor miRNAs.

Data sharing statement: we deposit our results in relevant online databases where available (e.g. http://www.ebi.ac.uk/pdbe) for release on publication. Other outputs will be distributed on request.

Currently our work is being funded by Cancer Research UK, the British Heart Foundation, the Medical Research Council, the Biotechnology and Biological Sciences Research Council, and the Wellcome Trust.

Professor Robert Gilbert Professor Robert Gilbert

Titles

  • Professor of Biophysics
  • Director, Medical Sciences Division Graduate School
  • Director of Graduate Studies, NDM
  • Managing Editor, European Biophysics Journal

Group Information

  • Cell signalling, adhesion and pore formation in human disease

Current Group

  • Sophie Williams Sophie
    Williams
  • Xiulian Yu Xiulian
    Yu
  • Harriet Lane-Serff Harriet
    Lane-Serff
  • Monica Mantri Monica
    Mantri
  • Susan Black Susan
    Black