Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Ni T., Jiao F., Yu X., Aden S., Ginger L., Williams SI., Bai F., Pražák V., Karia D., Stansfeld P., Zhang P., Munson G., Anderluh G., Scheuring S., Gilbert RJC.

Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.

DOI

10.1126/sciadv.aax8286

Type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

2020-01-31T00:00:00+00:00

Volume

6

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