Research

Professor E. Yvonne Jones

The structure of the RPTPmu trans dimer (Aricescu et al Science 2007)
Semaphorin-plexin recognition complex (Janssen et al Nature 2010)
Model for opposing RPTPsigma-proteoglycan functions (Coles et al Science 2011)

Yvonne Jones is Director of the Cancer Research UK Receptor Structure Research Group which is focused on the structural biology of extracellular recognition and signalling complexes. The core technique is protein crystallography, but the group aims to integrate high resolution structural information with correlative light and electron microscopy, as well as cell-based functional studies, to probe molecular mechanisms at the cell surface.

The group's research addresses fundamental questions about cell-cell signalling systems of importance to human health. How are signalling assemblies arranged? Which features are necessary for normal signal transduction into the cell? What mechanisms trigger dysfunctional signalling? The work ties into an extensive network of interdisciplinary local and international collaborations with the ultimate aim of learning how to manipulate these signalling systems for the design of new clinical therapies. Current projects within the group focus on signalling systems of importance in developmental biology. These include systems involved in cell guidance (e.g. semaphorin/plexin and ephrin/Eph signalling), cell adhesion (e.g. the role of RPTPmu mediated adhesion at adherens junctions and of proteoglycan-RPTPsigma interactions in neuronal cell outgrowth). The group also has an active programme of work on the mechanisms controlling signalling by the Wnt family of morphogens.

Professor E. Yvonne Jones Professor E. Yvonne Jones

Titles

  • Professor of Protein Crystallography
  • Joint Head Division of Structural Biology
  • Deputy Director Wellcome Trust Centre for Human Genetics

Group Information

  • Cancer Research UK Receptor Structure Research Group

Current Group

  • Miguel Leung Miguel
    Leung
  • Jim  Monistrol Jim
    Monistrol
  • Dimple Karia Dimple
    Karia
  • James Hillier James
    Hillier
  • Daniel Rozbesky Daniel
    Rozbesky
  • Gergely Nagy Gergely
    Nagy
  • Karl Harlos Karl
    Harlos
  • Vitul Jain Vitul
    Jain
  • Tao-Hsin Chang Tao-Hsin
    Chang
  • Alex Diwa Alex
    Diwa
  • Rainer Kaufmann Rainer
    Kaufmann
  • Weixian Lu Weixian
    Lu
  • Margaret Jones Margaret
    Jones
  • Yuguang Zhao Yuguang
    Zhao