Research

Professor David Stuart FRS

Viruses are attractive targets for study at the molecular level, since they are sufficiently simple that we may hope to achieve a rather complete understanding of their biology. In practice although their genomes are compact they display astonishing diversity, both in structure and function. Our attempts to relate structure to function have benefited from the developments in X-ray crystallographic methods that have brought very complex structures within reach of description in atomic detail. Our targets range from picornaviruses, small ssRNA viruses, which include a number of important animal and human pathogens, to the larger dsRNA viruses. At both ends of this spectrum (from less than 10,000,000 to about 100,000,000 Daltons) we now have representative atomic structures.

Our efforts are particularly focused on virus-receptor interactions and basic puzzles of virus assembly. Our studies here are highly collaborative, with strong links with a number of virologists (P. Mertens and B. Charleston (Pirbright), D. Rowlands (Leeds), P. Roy (London) as well as numerous groups elsewhere in Europe).

Work on cell-surface molecules is largely performed in collaboration with the group of Prof. E.Y. Jones, whose entry describes many of the projects.

We have a particular interest in studying virus evolution and many of these studies are perfoirmed in collaboration with D. Bamford in Helsinki.

Finally, we are studying a number of viral proteins and enzymes which are potential drug targets and/or illuminate how viruses modulate host responses. For example, the immune modulators of pox viruses.

Professor David Stuart FRS Professor David Stuart FRS

Titles

  • Professor of Structural Biology
  • Director of the Division of Structural Biology, MRC Research Professor, SPINE coordinator (Structura

Group Information

  • Viruses, Viral proteins and Cell surface receptors

Current Group

  • Margaret Jones Margaret
    Jones
  • Daming Zhou Daming
    Zhou
  • Karl Harlos Karl
    Harlos
  • Tom Walter Tom
    Walter
  • Yuguang Zhao Yuguang
    Zhao
  • Claudine Porta Claudine
    Porta
  • Helen Duyvesteyn Helen
    Duyvesteyn
  • Mattia Bertinelli Mattia
    Bertinelli
  • Mohammad Bahar Mohammad
    Bahar
  • Elizabeth Fry Elizabeth
    Fry
  • Salima Nurmohamed (Sarah) Salima
    Nurmohamed (Sarah)
  • Luigi De Colibus Luigi
    De Colibus
  • Jingshan Ren Jingshan
    Ren
  • Max Renner Max
    Renner
  • Weixian Lu Weixian
    Lu
  • Miquel Coll Miquel
    Coll
  • Mark Boyce Mark
    Boyce
  • Jonathan Elegheert Jonathan
    Elegheert
  • Hazel Aitkenhead Hazel
    Aitkenhead
  • Geoff Sutton Geoff
    Sutton
  • Oleg Iourin Oleg
    Iourin