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The long and short of microRNA

Cell 25th Apr 2013 Yates LA, Norbury CJ, Gilbert RJ,
  • Professor Robert Gilbert

MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is controlled by highly developed regulatory pathways and fine-tuning mechanisms both affecting miRNA processing and altering mature miRNA target specificity.