The Division of Structural Biology, as one of the largest structural biology laboratories in Europe, plays a significant role in coordinating European efforts in structural biology. The Division has a five-member team dedicated to working with the senior academics in the Division to foster international collaboration and help to realize the goal of integrated large-scale structural biology resources across Europe to allow world-leading research. An overview of the main projects is given below and full details about each project can be found on the relevant web sites.
STRUBI is the Coordinating member of Instruct, a project initiated within the European Strategy Forum for Research Infrastructures (ESFRI) to provide access to high value technologies and expertise for European structural cell biology. Initially funded by the EU under the Framework 7 programme, Instruct is now supported wholly by national and institutional funds from nine member countries. Instruct is open to access proposals, has an actively funded training programme and committed funding for six R&D awards in 2013. (Twitter: @instructhub).
P-cube is one of several projects funded through the EU Framework 7 Integrated Infrastructure Initiative to enable access to specialist technologies for structural biology. P-cube offers access to protein production and crystallization facilities by European researchers. P-cube is coordinated by the University of Zurich. STRUBI, along with OPPF-UK offers largely automated mammalian and bacterial expression and crystallization technologies including several biophysical techniques for protein characterization. STRUBI hosts the P-cube website.
Biostruct-X is another of the Integrated Infrastructure Initiatives in the same funding group as P-cube. Coordinated from EMBL-Hamburg, Biostruct-X provides access to X-ray facilities located at synchrotrons and the FEL in Hamburg. STRUBI is a partner in Biostruct-X providing protein sample production and crystallization platforms. Diamond Light Source is also a partner in Biostruct-X.
EMTRAIN is part of the European Medicines Initiative (IMI) and is jointly funded by the European Commission and EFPIA (European Pharmaceutical Industries and Associations). EMTRAIN has been set up to establish a sustainable pan-European platform for education and training, helping to integrate the strengths and competencies of the ESFRI Biomedical Sciences projects, one of which is Instruct. EMTRAIN is jointly coordinated by the University of Vienna and AstraZeneca. EMTRAIN also hosts on-course, an on-line catalogue of CPD and other training courses available in Europe.
BioMedBridges is a joint effort of ten Biomedical Sciences Research infrastructures on the ESFRI roadmap, aiming to develop a shared e-infrastructure—the technical bridges—to allow interoperability between data and services in the biological, medical, translational and clinical domains and thus strengthen biomedical resources in Europe. Instruct is a partner of BioMedBridges which is coordinated by EMBL-EBI.
Previous EU funded projects coordinated by STRUBI (now completed) include SPINE, SPINE2-Complexes and Teach-SG.
A special issue of Acta Cryst D (2006) vol 62/10 provides a summary of the achievements of SPINE.
The SPINE2-Complexes EU FP7 project special edition of the Journal of Structural Biology (2011) vol 175/2 is available as an open access publication!